Whereas very low-count MBL hardly ever progresses to CLL, significant-count MBL progresses to CLL demanding therapy in a rate of 1% to 2% a year. Superior-count MBL is distinguished from Rai 0 CLL based on if the B-mobile depend is earlier mentioned or down below five × 109/L. Despite the fact that people today with each higher-depend MBL and CLL